The present approach will allow investigators to correct for the relaxation-induced Lac signal loss in Sel-MQC experiments for the quantitative mapping of in vivo tumor Lac distribution. Research Publications Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia. The performance of these sequences was evaluated with the use of phantoms and subcutaneous murine tumor models in vivo. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. The T2-Sel-MQC sequence incorporates a CH3-selective 180 degrees pulse during the MQ preparation period to overcome the J-modulation effects and allow the insertion of variable echo delays. Work performed on phantoms showed good lactate detection(49) and lipid suppression (98) efciencies. The T1-Sel-MQC sequence combines an inversion prepulse with the Sel-MQC filter. Thisstudy presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQC-CSI), at1.5 T, to better quantify lactate in the presence of lipids. This work reports modifications to the Sel-MQC pulse sequence, T1- and T2-Sel-MQC, that facilitate relaxation measurements of Lac. Conversion of the detected signal into accurate tissue concentrations of Lac requires knowledge of in vivo Lac T1 and T2 relaxation times.
Selective multiple quantum coherence lactate series#
This method utilized a series of pulses to select for specific quantum coherence transfer pathways for lactate vs lipid.
tiple quantum coherence: FE, fractional enrichment. One early technique for multiple quantum filtered selective lactate spectroscopy was the selective homonuclear multiple quantum coherence transfer (SelMQC) technique. The frequency-selective multiple-quantum-coherence (Sel-MQC) lactate (Lac) filter offers complete lipid and water suppression in a single scan for robust in vivo detection of tumor Lac, even in the presence of abundant lipids. In studies of experimental tumors, several groups have also dem-. The selective multiple quantum coherence technique is combined with a read gradient to accelerate the measurement of a specific scalar-coupled metabolite.
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